3030492-59-9

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3030492-59-9 Structure

Identification	Back Directory
[Name] Ebselen derivative 1
[CAS] 3030492-59-9
[Synonyms] Ebselen derivative 1
[MOL File] 3030492-59-9.mol
[Molecular Weight] 305.19

Chemical Properties	Back Directory
[Boiling point ] 471.676±51.00 °C(Press: 760.00 Torr)(predicted)
[pka] 4.294±0.12(predicted)

Hazard Information	Back Directory
[Uses] Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss [1].
[in vivo] Ebselen derivative 1 (Compound 19) (80 mg/kg; oral administration; once daily for one week) exhibites hearing protective effects in C57BL/6 mice, mitigating the hair cell loss induced by cisplatin (5 mg/kg; i.p.; administered once on the third and seventh days of Ebselen derivative 1 treatment) (HY-17394)^[1].
[References] [1] Wang W, et al. Quantum chemistry calculation-aided discovery of potent small-molecule mimics of glutathione peroxidases for the treatment of cisplatin-induced hearing loss. Eur J Med Chem. 2024;271:116404. DOI:10.1016/j.ejmech.2024.116404

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