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ChemicalBook--->CAS DataBase List--->3025012-68-1

3025012-68-1

3025012-68-1 Structure

3025012-68-1 Structure
IdentificationBack Directory
[Name]

DNMT1-IN-3
[CAS]

3025012-68-1
[Synonyms]

DNMT1-IN-3
[Molecular Formula]

C23H13Cl3N2O4
[MOL File]

3025012-68-1.mol
[Molecular Weight]

487.72
Chemical PropertiesBack Directory
[Boiling point ]

650.6±55.0 °C(predicted)
[density ]

1.63±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

3.24±0.10(predicted)
Hazard InformationBack Directory
[Uses]

DNMT1-IN-3 (compound 7t-S) is an effective DNA methyltransferase 1 (DNMT1) inhibitor with an IC50 value of 0.777 μM and a KD value of 0.183 μM. DNMT1-IN-3 can bind to the methyl donor S-adenosyl-l-methionine (SAM) site in DNMT1. DNMT1-IN-3 can inhibit cell proliferation in K562 cells by inducing cells apoptosis and arresting cell cycle at G0 / G1 phase, which has the potential to be used for the research of hematologic tumor[1].
[IC 50]

DNMT1: 0.777 μM (IC50)
[References]

[1] Liu J, et al. Identification of 3-(9H-carbazol-9-yl)-2-(1,3-dioxoisoindolin-2-yl)propanoic acids as promising DNMT1 inhibitors. Eur J Med Chem. Published online May 27, 2024. DOI:10.1016/j.ejmech.2024.116538
3025012-68-1 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Tags:3025012-68-1 Related Product Information

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