| Identification | Back Directory | [Name]
BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- | [CAS]
300586-90-7 | [Synonyms]
OAC1
CS-2147
OAC1;OAC-1
OAC1, >98%
BAS 00287861
OAC1;OAC-1;OAC 1
OAC1 (BAS 00287861)
OAC1;OAC-1;OAC 1;BAS 00287861
iPSC Induction Enhancer II, OAC1
N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide
N-(1H-pyrrolo[3,2-d]pyridin-5-yl)benzamide
BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-
iPSC Induction Enhancer II, OAC1 - CAS 300586-90-7 - Calbiochem | [Molecular Formula]
C14H11N3O | [MDL Number]
MFCD00572806 | [MOL File]
300586-90-7.mol | [Molecular Weight]
237.257 |
| Chemical Properties | Back Directory | [Boiling point ]
386.6±22.0 °C(Predicted) | [density ]
1.363±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
11.76±0.43(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
OAC1 enhances iPSC reprogramming efficiency. | [General Description]
A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1 μM OAC1 treatment starts 48 h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294 (Cat. No. 382190), Tranylcypromine (Cat. No. 616431), VPA (Cat. No. 676380), and Vitamin C (Cat. No. 1813), in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO (Cat. No. 361550) is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. | [Biochem/physiol Actions]
Cell permeable: yes | [in vivo]
OAC1 (50000 CB CD34+ cells with OAC1(500 nM); i.h.; 16 weeks) enhances short and long-term engrafting hematopoietic stem cells (HSC) in irradiated NSG mice[2]. | Animal Model: | Irradiated NSG mice with OAC1 or vehicle control treated CB CD34+ cells within 24h after irradiation[2] | | Dosage: | 16 weeks | | Administration: | Subcutaneous injection OAC1(500 nM) treated CB CD34+ cells | | Result: | Increased cord blood (CB) cells in primary recipients, compared to the vehicle control group, with the board increase for human B cells, T cells, and myeloid cells in the bone marrow (BM) of primary recipients, resulting in a significant expansion of SRC numbers. |
| [IC 50]
TET1 | [storage]
Store at -20°C |
|
| Company Name: |
TCI Europe
|
| Tel: |
320-37350700 |
| Website: |
https://www.tcichemicals.com/de/de/index.html |
| Company Name: |
TCI AMERICA
|
| Tel: |
800-4238616 |
| Website: |
https://www.tcichemicals.com/en/us/index.html |
|