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ChemicalBook--->CAS DataBase List--->2999794-78-2

2999794-78-2

2999794-78-2 Structure

2999794-78-2 Structure
IdentificationBack Directory
[Name]

NNRT-IN-2
[CAS]

2999794-78-2
[Synonyms]

NNRT-IN-2
Hazard InformationBack Directory
[Uses]

NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC50 of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics[1].
[References]

[1] Zhao LM, et al. Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility. Acta Pharm Sin B. 2023 Dec;13(12):4906-4917. DOI:10.1016/j.apsb.2023.07.008
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