| Chemical Properties | Back Directory | [Boiling point ]
535.068±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.477±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
12.939±0.70(predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 induces apoptosis and arrest cell cycle at G2/M phase. PARP-1-IN-3 can be used in research of cancer[1]. | [IC 50]
PARP-1: 0.25 nM (IC50); PARP-2: 2.34 nM (IC50) | [References]
[1] Lu G, et, al. Discovery of novel benzamide derivatives bearing benzamidophenyl and phenylacetamidophenyl scaffolds as potential antitumor agents via targeting PARP-1. Eur J Med Chem. 2023 May 5;251:115243. DOI:10.1016/j.ejmech.2023.115243 |
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