| Identification | Back Directory | [Name]
1H-Pyrazolo[3,4-b]pyridin-3(2H)-one | [CAS]
2942-43-0 | [Synonyms]
1h-pyrazolo[3,4-b]pyridin-3-ol
1H-Pyrazolo[3,4-b]pyridin-3(2H)
1H,2H-pyrazolo[3,4-b]pyridin-3-one
1H-Pyrazolo[3,4-b]pyridin-3(2H)-one
3-Hydroxy-1H-pyrazolo[3,4-b]pyridine
1,2-dihydropyrazolo[3,4-b]pyridin-3-one
1,2-Dihydro-3H-pyrazolo[3,4-b]pyridin-3-one
3H-Pyrazolo[3,4-b]pyridin-3-one, 1,2-dihydro- | [Molecular Formula]
C6H5N3O | [MDL Number]
MFCD03013435 | [MOL File]
2942-43-0.mol | [Molecular Weight]
135.12 |
| Chemical Properties | Back Directory | [Melting point ]
234-236° | [density ]
1.62±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
8.93±0.20(Predicted) | [Appearance]
Yellow to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-one from ethyl 2-chloropyridine-3-carboxylate: a mixed solution of 5 g (26.94 mmol) of ethyl 2-chloropyridine-3-carboxylate and 4.76 g (80.82 mmol) of 85% hydrazine hydrate in 10 ml of ethanol was heated and refluxed for 6 hours. After completion of the reaction, the reaction mixture was concentrated. The product 3.5 g was obtained in 96% yield and the [M+H]+ peak was detected as 135.9 by mass spectrometry. | [References]
[1] Patent: WO2005/73199, 2005, A1. Location in patent: Page/Page column 31
[2] Patent: US2005/197348, 2005, A1. Location in patent: Page/Page column 10 |
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