| Identification | Back Directory | [Name]
pan-KRAS degrader 1 | [CAS]
2937327-83-6 | [Synonyms]
pan-KRAS degrader 1
(4S)-2-amino-4-methyl-4-[3-[2-[(2S)-2-methyl-1,4-diazepan-1-yl]pyrimidin-4-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-benzothiophene-3-carbonitrile |
| Hazard Information | Back Directory | [Uses]
pan-KRAS degrader 1 (Compound 1) is a panKRAS degrader with a surface plasmon resonance (SPR) dissociation constant Ki value of 25 nM for KRASG12V .pan-KRAS degrader 1 has antitumor activity[1]. | [References]
[1] Popow J, et al. Targeting cancer with small-molecule pan-KRAS degraders. Science. 2024 Sep 20;385(6715):1338-1347. DOI:10.1126/science.adm8684 |
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