| Hazard Information | Back Directory | [Uses]
HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC50 value of 3.5 nM. HPK1-IN-35 decreases the expression of p-SLP76 and promotes IL-2 secretion[1]. | [IC 50]
HPK1: 3.5 nM (IC50) | [References]
[1] Feifei Wu, et al. Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. European Journal of Medicinal Chemistry. 2023, 254: 115355. |
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