| Hazard Information | Back Directory | [Uses]
ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER)α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness[1]. | [IC 50]
ERα | [References]
[1] Deng X, et al. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11094-11117. DOI:10.1021/acs.jmedchem.3c00465 |
|
|