| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
145-147°C | [storage temp. ]
2-8°C
| [solubility ]
DMSO: ~11 mg/mL
| [form ]
solid
| [color ]
off-white
| [Water Solubility ]
Soluble in DMSO at 2mg/ml. Insoluble in water | [InChI]
InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H | [InChIKey]
KBFUQFVFYYBHBT-UHFFFAOYSA-N | [SMILES]
N1(C(C2=CC=CC=C2Cl)(C2=CC=CC=C2)C2=CC=CC=C2)C=CC=N1 | [CAS DataBase Reference]
289905-88-0 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
TRAM-34 blocks intermediate conductance calcium-activated potassium channel IKCa1 with a Kd of 20nM and exhibits exquisite selectivity for the channel. Clotrimazole impurity. | [Biological Activity]
Highly selective blocker of intermediate conductance Ca 2+ -activated K + channels (IK Ca 1, K Ca 3.1) (K d = 20 nM). Exhibits 200-1500-fold selectivity over K V , BK Ca , SK Ca , Na + , CRAC and Cl - channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli. | [Definition]
ChEBI: TRAM-34 is an organochlorine compound. | [Biochem/physiol Actions]
TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,. | [storage]
Store at -20°C |
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