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ChemicalBook--->CAS DataBase List--->28874-45-5

28874-45-5

28874-45-5 Structure

28874-45-5 Structure
IdentificationBack Directory
[Name]

CANTHARIDIC ACID
[CAS]

28874-45-5
[Synonyms]

CANTHARIDIC ACID
CANTHARIDIC ACID DISODIUM SALT
Cantharidic Acid - CAS 28874-45-5 - Calbiochem
5'-3'2,3-DICARBOXY-2,3-DIMETHYL-1,4-EPOXYCYCLOHEXANE
EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYCLO[2,2,1]HEPTANE
EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYLCO[2,2,1]HEPTANE
[Molecular Formula]

C8H10O5
[MDL Number]

MFCD00047137
[MOL File]

28874-45-5.mol
[Molecular Weight]

186.16
Chemical PropertiesBack Directory
[Melting point ]

216-218℃
[Boiling point ]

407.8±40.0 °C(Predicted)
[density ]

1.359±0.06 g/cm3(Predicted)
[storage temp. ]

+15C to +30C
[solubility ]

Soluble in DMSO (100 mM) and in ethanol (25 mM, gentle warming)
[form ]

White solid
[pka]

3.70±0.40(Predicted)
[color ]

white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Hazard statements ]

H315
[Precautionary statements ]

P264-P280g-P302+P352a-P321-P332+P313-P362+P364
[Hazard Codes ]

Xi
[Risk Statements ]

38
[Safety Statements ]

22-36/37/39
Hazard InformationBack Directory
[Uses]

Potent and selective inhibitor of PP2A, IC50=53nM (IC50 for PP1=562nM). Useful for inhibiting PP1 and PP2A during purification of phosphorylated proteins.
[Definition]

ChEBI: A monoterpenoid with an epoxy-bridged bicyclic dicarboxylic acid structure, which acts as an inhibitor of protein phosphatases 1 and 2A.
[Biological Activity]

Cell permeable: no''Primary Target
PP2A''Product does not compete with ATP.''Reversible: no''Target IC50: 50 nM against protein phosphatase 2A
[storage]

Room temperature
[References]

[1] Chen YC, et al., Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627. DOI:10.1002/tox.22897
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