| Identification | Back Directory | [Name]
8(Z),10(E),12(Z)-OCTADECATRIENOIC ACID | [CAS]
28872-28-8 | [Synonyms]
JACARIC ACID
8(Z),10(E),12(Z)-OCTADECATRIENOIC ACID
(8E,10Z,12Z)-Octadeca-8,10,12-trienoic acid | [Molecular Formula]
C18H30O2 | [MDL Number]
MFCD05864027 | [MOL File]
28872-28-8.mol | [Molecular Weight]
278.43 |
| Chemical Properties | Back Directory | [Boiling point ]
423.4±24.0 °C(Predicted) | [density ]
0.924±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C, Light sensitive | [solubility ]
Ethanol (Soluble) | [form ]
Colourless Solution | [pka]
4.77±0.10(Predicted) | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells. Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 μM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice. | [Uses]
8(Z),10(E),12(Z)-Octadecatrienoic Acid, is a conjugated Linoleic Acid, a compound that has reported to exhibit anticarcinogenic activity. Also a potent antioxidant. | [Uses]
Jacaric Acid (10mg/mL in Ethanol) is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. | [Definition]
ChEBI: 8Z,10E,12Z-octadecatrienoic acid is an octadecatrienoic acid. | [in vivo]
Jacaric acid (1 mg/day/mouse, p.o. for 36 days) exhibits antitumor activity in DLD-1 transplanted athymic nude mice, without significant toxicity[2]. | Animal Model: | DLD-1 xenograft athymic nude mice[2] | | Dosage: | 1 mg/mouse | | Administration: | p.o. for 36 days | | Result: | Reduced tumor volume without significant weight loss in body and liver. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Boao Pike
|
| Tel: |
010-57798038 15652371397 |
| Website: |
www.biopike.cn |
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