| Identification | Back Directory | [Name]
2H-Benzimidazole-2-thione, 5-[[(2,4-dihydroxyphenyl)methylene]amino]-1,3-dihydro- | [CAS]
2870693-28-8 | [Synonyms]
α-Glucosidase-IN-22
5-((2,4-Dihydroxybenzylidene)amino)-1,3-dihydro-2H-benzo[d]imidazole-2-thione
2H-Benzimidazole-2-thione, 5-[[(2,4-dihydroxyphenyl)methylene]amino]-1,3-dihydro- | [Molecular Formula]
C14H11N3O2S | [MOL File]
2870693-28-8.mol | [Molecular Weight]
285.32 |
| Chemical Properties | Back Directory | [Boiling point ]
556.5±52.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.43±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
α-Glucosidase-IN-22 (compound 7i), a benzimidazole, is a potent α-glucosidase inhibitor with an IC50 of 0.64 μM. α-Glucosidase-IN-22 is a potent anti-diabetic agent and has the potential for type 2 diabetes mellitus (T2DM) research[1]. | [References]
[1] Sardar Ali, et al. Novel 5-(Arylideneamino)-1?H-Benzo[?d]imidazole-2-thiols as Potent Anti-Diabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition, and Molecular Docking Studies. ACS Omega. 2022 Nov 23;7(48):43468-43479. DOI:10.1021/acsomega.2c03854 |
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