午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook--->CAS DataBase List--->2866179-95-3

2866179-95-3

2866179-95-3 Structure

2866179-95-3 Structure
IdentificationBack Directory
[Name]

Bleximenib oxalate
[CAS]

2866179-95-3
[Synonyms]

Bleximenib oxalate
[Molecular Formula]

C32H50FN7O3.C2H2O4
[MOL File]

2866179-95-3.mol
[Molecular Weight]

689.82
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Light yellow to yellow
[InChIKey]

OYKHOVACUSUKFI-OSMNJKESNA-N
[SMILES]

[C@H](N1CC2(CCN(C3=NC=NN=C3OC3C=CC(=CC=3C(=O)N(CC)C(C)C)F)C2)C1)(C(C)C)CCCN(C)CCOC.C(=O)(O)C(=O)O |&1:0,r|
Hazard InformationBack Directory
[Uses]

Bleximenib (JNJ-75276617; Menin-MLL inhibitor 24) oxalate is a potent, selective and orally active menin-KMT2A protein-protein interaction inhibitor with IC50 values of 0.1, 0.045, ≤0.066 nM for human, mouse, dog, respectively. Bleximenib oxalate shows antiproliferative activity and induces apoptosis. Bleximenib oxalate has the potential for the research of Acute myeloid leukemia (AML)[1][2].
[in vivo]

Bleximenib (30, 50, 100 mg/kg; PO; daily for 5 weeks) oxalate shows antitumor activity[1].

Animal Model:6- to 8-week-old immune-compromised mice (MOLM-14 AML)[1]
Dosage:30, 50, 100 mg/kg
Administration:PO; daily for 5 weeks
Result:Induced tumor regressions of 70%, 97%, and 99% at 30, 50, and 100 mg/kg, respectively.
[References]

[1] Kwon MC, et al. Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias. Blood. 2024 Sep 12;144(11):1206-1220. DOI:10.1182/blood.2023022480
[2] Hogeling SM, et al. Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia. Haematologica. 2024 Dec 19. DOI:10.3324/haematol.2024.285616
2866179-95-3 suppliers list
Company Name: Hangzhou ICH Biofarm Co., Ltd
Tel: +86-0571-28186870; +undefined8613073685410 , +undefined8613073685410
Website: http://www.ichemie.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: Suzhou Haiben Pharmaceutical Co., Ltd  Gold
Tel: 19353112242
Website:
Company Name: Shanghai CR Corporation Limited  
Tel: 13062833949; 4006653949 4006653949
Website: www.crcorporation.cn
Company Name: Bide Pharmatech Ltd.  
Tel: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: Jiangsu Boquan Biotechnology Co., Ltd.  
Tel: 19025100081
Website: m.boquanshengwu.com
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: Soochow Chirally Material Science and Technology Co.,Ltd  
Tel: 0512-66834346 17751187418
Website: www.krl-tech.com/
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Website: www.ruidiresearch.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Shandong Boyi Biotechnology Co., Ltd  
Tel: 17372913111
Website:
Company Name: Selleck Chemicals  
Tel: 400-668-6834
Website: www.selleckchem.com
Tags:2866179-95-3 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.