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HSD17B13-IN-99 (Compound 6) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-99 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI)[1]. | [References]
[1] Joshua Odingo, et al. Hydroxypyridine hsd17b13 inhibitors and uses thereof. U.S., WO2022216626. 2022-10-13. |
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