| Identification | Back Directory | [Name]
1-Piperidinecarbonitrile, 4-[4-[3-chloro-4-[(1R)-1-(2-cyanophenyl)ethoxy]pyrazolo[1,5-a]pyridin-6-yl]-5-methyl-1H-pyrazol-1-yl]- | [CAS]
2833706-13-9 | [Synonyms]
FGFR3-IN-4
1-Piperidinecarbonitrile, 4-[4-[3-chloro-4-[(1R)-1-(2-cyanophenyl)ethoxy]pyrazolo[1,5-a]pyridin-6-yl]-5-methyl-1H-pyrazol-1-yl]- | [Molecular Formula]
C26H24ClN7O | [MOL File]
2833706-13-9.mol | [Molecular Weight]
485.97 |
| Hazard Information | Back Directory | [Uses]
FGFR3-IN-4 is a selective FGFR3 inhibitor, with an IC50 value of less than 50 nM. FGFR3-IN-4 is at least 10 fold more selective for FGFR3 than for FGFR1[1]. | [IC 50]
FGFR3: < 50 nM (IC50) | [References]
[1] Abraham, et al. Preparation of substituted pyrazolo[1,5-a]pyridine-3-carbonitriles and imidazo[1,2-a]pyridine-3-carbonitriles as FGFR3 inhibitors. WO2022187443. |
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