| Identification | Back Directory | [Name]
2-Piperazinecarboxamide, 4-(2-chloroacetyl)-1-(3,4-dichlorophenyl)-N-(2-thienylmethyl)-, (2S)- | [CAS]
2768834-48-4 | [Synonyms]
SARS-CoV-2 Mpro-IN-6
2-Piperazinecarboxamide, 4-(2-chloroacetyl)-1-(3,4-dichlorophenyl)-N-(2-thienylmethyl)-, (2S)- | [Molecular Formula]
C18H18Cl3N3O2S | [MOL File]
2768834-48-4.mol | [Molecular Weight]
446.78 |
| Hazard Information | Back Directory | [Uses]
SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 Mpro inhibitor with an IC50?of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3[1]. | [References]
[1] Shenghua Gao, et al. Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors. J Med Chem. 2022 Dec 22;65(24):16902-16917. DOI:10.1021/acs.jmedchem.2c01716 |
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