102520-97-8

27646-80-6

General procedure for the synthesis of 2-methyl-2-methylamino-1-propanol from 2-(Boc-amino)-2-methyl-1-propanol: tert-butyl 1-hydroxy-2-methylpropan-2-ylcarbamate (67 g, 354 mmol) was slowly added dropwise under nitrogen protection and at 0 °C to a tetrahydrofuran (THF) solution (150 mL) of LiAlH4 ( 40.3 g, 1062 mmol) in a tetrahydrofuran (THF) solution (400 mL) under stirring. The reaction mixture was stirred at 90 °C overnight and then cooled, followed by quenching by sequential addition of water (40.5 mL), 15% aqueous NaOH solution (40.5 mL) and water (40.5 mL) at 0 °C. The mixture was continued to be stirred for 1 hour and then filtered through diatomaceous earth. The organic layer was dried with sodium sulfate and concentrated in vacuum to give 2-methyl-2-methylamino-1-propanol (28 g, 77% yield) without further purification.LC-MS (ESI) analysis: m/z 104 [M + H]+; retention time 0.24 min.