| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-[(2,4-dimethoxyphenyl)amino]-5,7-diphenyl- | [CAS]
2761858-59-5 | [Synonyms]
CDK1-IN-1
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-[(2,4-dimethoxyphenyl)amino]-5,7-diphenyl- | [Molecular Formula]
C27H23N5O3 | [MOL File]
2761858-59-5.mol | [Molecular Weight]
465.5 |
| Hazard Information | Back Directory | [Uses]
CDK1-IN-1 is a potent CDK1 inhibitor (CDK1/CycB IC50=161.2 nM) with potential antiproliferative activity and selectivity for cancer tissues. CDK1-IN-1 induces apoptosis in p53 dependent manner through the intrinsic apoptotic pathway. CDK1-IN-1 is a potential targeted antitumor agent[1]. | [IC 50]
CDK1/cycB: 161.2 nM (IC50) | [References]
[1] Elgiushy HR, et al. Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105646. DOI:10.1016/j.bioorg.2022.105646
[2] Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802. DOI:10.1021/acs.jpclett.0c03119 |
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