| Identification | Back Directory | [Name]
Baccatine III | [CAS]
27548-93-2 | [Synonyms]
baccatin Ⅲ
NSC 330753
BACCATIN III
BACCATINE III
BACCATIN III 98%
Baccatine III,95%
Baccatin III >=95% (HPLC)
(1S)-4α,10β-Bis(acetoxy)-2α-(benzoyloxy)-5β,20-epoxy-1,7β,13α-trihydroxytaxa-11-ene-9-one
6α,12bβ-Diacetoxy-12β-benzoyloxy-1,2aβ,3,4,4a,6,9,10,11,12,12aβ,12b-dodecahydro-4α,9β,11β-trihydroxy-4aα,8,13,13-tetramethyl-7,11α-methano-5H-cyclodeca[3,4]benzo[1,2-b]oxete-5-one
(2aR)-6α,12bβ-Diacetoxy-12β-benzoyloxy-1,2aβ,3,4,4a,6,9,10,11,12,12aβ,12b-dodecahydro-4α,9β,11β-trihydroxy-4aα,8,13,13-tetramethyl-7,11α-methano-5H-cyclodeca[3,4]benzo[1,2-b]oxete-5-one
(2aR)-6α,12bβ-Bisacetoxy-12β-(benzoyloxy)-1,2aβ,3,4,4a,6,9,10,11,12,12aβ,12b-dodecahydro-4α,9β,11β-trihydroxy-4aα,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benzo[1,2-b]oxete-5-one
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetraMethyl-7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetraMethyl-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)- | [Molecular Formula]
C31H38O11 | [MDL Number]
MFCD00153921 | [MOL File]
27548-93-2.mol | [Molecular Weight]
586.63 |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Powder | [Melting point ]
229-234 °C
| [Boiling point ]
562.81°C (rough estimate) | [density ]
1.2062 (rough estimate) | [refractive index ]
1.5455-1.5475
| [storage temp. ]
2-8°C
| [solubility ]
DMSO : 125 mg/mL (213.08 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.76±0.70(Predicted) | [color ]
White to off-white | [Water Solubility ]
insoluble | [Stability:]
4 Year Shelf Life | [CAS DataBase Reference]
27548-93-2 |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Powder | [Uses]
A precursor to Paclitaxel, a neoplasm inhibitor to ovarian and breast cancers found in Taxus species | [Uses]
immunomodulator, induces apoptosis | [Definition]
ChEBI: A tetracyclic diterpenoid isolated from plant species of the genus Taxus. | [in vivo]
Baccatin III (0.05-0.5 mg/kg; intragastrically; once daily; 17-19 days) significantly inhibits tumor growth and reduced accumulation of myeloid-derived suppressor cells (MDSCs) in BALB/c mice with 4T1 breast cancer or CT26 colon cancer[1].
Baccatin III (5-10 mg/kg; intraperitoneally; single; 21 days) alleviates Bleomycin (HY-108345)-induced lung fibrosis in C57BL/6 mice by inhibiting TGF-β1[2]. | [storage]
Store at -20°C |
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