Identification | Back Directory | [Name]
Benzoic acid, 4-[2-[[[(2E)-2-[(5-cyano-7-methyl-1H-indol-3-yl)methylene]hydrazinyl]iminomethyl]amino]ethyl]-, methyl ester | [CAS]
2752378-78-0 | [Synonyms]
RXFP3/4 agonist 2 Benzoic acid, 4-[2-[[[(2E)-2-[(5-cyano-7-methyl-1H-indol-3-yl)methylene]hydrazinyl]iminomethyl]amino]ethyl]-, methyl ester | [Molecular Formula]
C22H22N6O2 | [MOL File]
2752378-78-0.mol | [Molecular Weight]
402.45 |
Chemical Properties | Back Directory | [Boiling point ]
638.3±65.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
14.75±0.30(Predicted) | [color ]
White to pink |
Hazard Information | Back Directory | [Description]
RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1]. | [Uses]
RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1]. | [References]
[1] Guan D, et al. Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies. J Med Chem. 2021;64(24):17866-17886. DOI:10.1021/acs.jmedchem.1c01081 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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