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Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to TNFSF15/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS). Duvakitug can be used in the study of Crohn's Disease (CD)[1][2]. | [in vivo]
Duvakitug reduces the inflammation and fibrosis in colitis animal models, and can be used in research of ulcerative colitis (UC) and Crohn’s disease[3]. | [References]
[1] Gonsky, et al. Intestinal mononuclear phagocytes as prognostic biomarker for Crohn's disease. World Intellectual Property Organization, WO2023102051 A1. 2023-06-08. [2] Duvakitug. IMGT/mAb-DB. [3] Reinisch W, et al. OP41 Duvakitug (TEV-48574), an anti-TL1a monoclonal antibody, demonstrates efficacy and favourable safety as an induction treatment in adults with moderately to severely active ulcerative colitis: Results from a phase 2b, randomised, double-blind, placebo-controlled, dose-ranging, basket trial (RELIEVE UCCD)[J]. Journal of Crohn's and Colitis, 2025, 19(Supplement_1): i79-i80. |
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