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ChemicalBook--->CAS DataBase List--->2749370-85-0

2749370-85-0

2749370-85-0 Structure

2749370-85-0 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2749370-85-0
[Synonyms]

[Molecular Formula]

C24H27NO5S
[MOL File]

2749370-85-0.mol
[Molecular Weight]

441.54
Chemical PropertiesBack Directory
[solubility ]

Methanol: soluble
[form ]

A solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
Hazard InformationBack Directory
[Description]

Troglitazone-d4 is intended for use as an internal standard for the quantification of troglitazone by GC- or LC-MS. Troglitazone is a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay).1 It is selective for PPARγ over PPARα and PPARδ, at which it is inactive at concentrations up to 10 μM. Troglitazone (500 mg/kg twice per day) exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87%, respectively.2 It also induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells when used at a concentration of 10 μM and increases apoptosis in these cells at concentrations of 30 μM and higher.3
[Uses]

Troglitazone-d4 is deuterium labeled Troglitazone. Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine?PPARγ receptor, respectively.
[References]

1. Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery J. Med. Chem. 43(4),527-550(2000).
2. Henke, B.R., Blanchard, S.G., Brackeen, M.F., et al. N-(2-Benzoylphenyl)-L-tyrosine PPARγ agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents J. Med. Chem. 41(25),5020-5036(1998).
3. Yoshizawa, K., Cioca, D.P., Kawa, S., et al. Peroxisome proliferator-activated receptor γ ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines Cancer 95(10),2243-2251(2002).
2749370-85-0 suppliers list
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
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Company Name: Hubei Rhema Reference Materials Technology Co., Ltd.  
Tel: 0712-8899838 15787879035
Website: www.yuhua99.com/supplier/138770565/
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Website: www.caymanchem.com
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