| Identification | Back Directory | [Name]
Naphtho[2,3-b]furan-2-carboxamide, N-[2-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]-1-piperidinyl]ethyl]-4,9-dihydro-4,9-dioxo- | [CAS]
2710221-08-0 | [Synonyms]
Naphtho[2,3-b]furan-2-carboxamide, N-[2-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]-1-piperidinyl]ethyl]-4,9-dihydro-4,9-dioxo- | [Molecular Formula]
C38H39N5O8 | [MOL File]
2710221-08-0.mol | [Molecular Weight]
693.74 |
| Hazard Information | Back Directory | [Uses]
XD2-149 is a PROTAC targeting STAT3. XD2-149 consists of PROTAC target protein ligand Napabucasin (HY-13919) (red part), E3 ligase Thalidomide (HY-14658) (black part), and linker NH2-C5-Azacyclohexane-N-Boc (HY-159572) (blue part). The E3 ligase + linker conjugate is Thalidomide-NH-C5-azacyclohexane-N-Boc (HY-159571), and the active control of the target protein ligand is Thalidomide acid (HY-159573)[1]. | [References]
[1] Hanafi M, et al. Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91. J Med Chem. 2021 Feb 11;64(3):1626-1648. DOI:10.1021/acs.jmedchem.0c01897 |
|
| Company Name: |
BIO- S
|
| Tel: |
19143500486 |
| Website: |
|
|