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ChemicalBook--->CAS DataBase List--->2705841-53-6

2705841-53-6

2705841-53-6 Structure

2705841-53-6 Structure
IdentificationBack Directory
[Name]

8RK59
[CAS]

2705841-53-6
[Synonyms]

8RK59
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2mg/mL, clear
[form ]

powder
[color ]

Faint orange to red
Hazard InformationBack Directory
[Uses]

8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1].
[Biological Activity]

8RK59 is a cellularly active covalent fluorescent probe th at targets selectively active UCHL1 (ubiquitin carboxy-terminal hydrolase L1). 8RK59 selectively and spatiotemporally report UCHL1 activity in zebrafish embryos.
[References]

[1] Kooij R, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. DOI:10.1021/jacs.0c07726
2705841-53-6 suppliers list
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Tel: +17819995354 , +17819995354
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Company Name: TargetMol Chemicals Inc.  
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Company Name: Merck KGaA  
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