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ChemicalBook--->CAS DataBase List--->2685738-33-2

2685738-33-2

2685738-33-2 Structure

2685738-33-2 Structure
IdentificationBack Directory
[Name]

ER-001259851-000
[CAS]

2685738-33-2
[Synonyms]

ER-001259851-000
[Molecular Formula]

C36H41FN8O4
[MOL File]

2685738-33-2.mol
[Molecular Weight]

668.76
Chemical PropertiesBack Directory
[density ]

1.343±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[pka]

10.41±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

ER-851 is a selective AXL inhibitor with oral activity with IC50 of 100 nM. ER-851 has antitumor activity[1].
[in vivo]

ER-851 (1-100 mg/kg, gavage once a day) inhibits tumor growth in mouse tumor models with xenografted HeLa and HCC1806 cells[1].

[References]

[1] Tsukamoto S, et al. ER-851, a Novel Selective Inhibitor of AXL, Overcomes Resistance to Antimitotic Drugs. Mol Cancer Ther. 2023 Jan 3;22(1):12-24. DOI:10.1158/1535-7163.MCT-21-0879
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