| Identification | Back Directory | [Name]
5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- | [CAS]
2681278-09-9 | [Synonyms]
IRAK4-IN-10
5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- | [Molecular Formula]
C22H24N8 | [MOL File]
2681278-09-9.mol | [Molecular Weight]
400.48 |
| Hazard Information | Back Directory | [Uses]
IRAK4-IN-10 (compound 75) is a potent IRAK4 inhibitor with an IC50 of 1.5 nM. IRAK4-IN-10 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer[1]. | [IC 50]
IRAK4: 1.5 nM (IC50) | [References]
[1] Sabnis RW. Novel Tricyclic Heteroaryl Compounds as IRAK4 Inhibitors for Treating Cancer, Autoimmune and Inflammatory Diseases. ACS Med Chem Lett. 2022 Feb 28;13(3):336-337. DOI:10.1021/acsmedchemlett.2c00060 |
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