| Identification | Back Directory | [Name]
1-(3-BroMo-2-Methoxyphenyl)ethanone | [CAS]
267651-23-0 | [Synonyms]
3'-Bromo-2'-methoxyacetophenone
3'-Bromo-2'-methoxyacetophenone97%
1-(3-BroMo-2-Methoxyphenyl)ethanone
3'-Bromo-2'-methoxyacetophenone 97%
Ethanone, 1-(3-bromo-2-methoxyphenyl)-
1-(3-bromo-2-methoxyphenyl)ethan-1-on
e
1-(3-Bromo-2-methoxyphenyl)ethan-1-one, 2-Acetyl-6-bromoanisole | [Molecular Formula]
C9H9BrO2 | [MDL Number]
MFCD22573042 | [MOL File]
267651-23-0.mol | [Molecular Weight]
229.071 |
| Chemical Properties | Back Directory | [Boiling point ]
290.5±25.0 °C(Predicted) | [density ]
1.421±0.06 g/cm3(Predicted) | [refractive index ]
1.5580 to 1.5630 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
liquid | [color ]
Clear, faint to light yellow | [InChI]
InChI=1S/C9H9BrO2/c1-6(11)7-4-3-5-8(10)9(7)12-2/h3-5H,1-2H3 | [InChIKey]
IBHCVANJIBGASI-UHFFFAOYSA-N | [SMILES]
C(=O)(C1=CC=CC(Br)=C1OC)C |
| Hazard Information | Back Directory | [Uses]
1-(3-Bromo-2-methoxyphenyl)ethanone is used as a reagent in the preparation of Tyrosine-Derived Benzofuranones. | [Synthesis]
The general procedure for the synthesis of 1-(3-bromo-2-methoxyphenyl)ethanone from the compound (CAS:267651-22-9) was as follows: ruthenium complex 2 (5 mol%), KOH (15 mol%), alcohol (5 mmol), and H2O (1.0 mL) were added to a Schlenk tube. The reaction mixture was stirred under reflux conditions for 48 hours. After completion of the reaction, the product was extracted with dichloromethane. Subsequently, all dichloromethane was evaporated under vacuum and the target products, ketones and aldehydes, were isolated from the crude mixture by column chromatography using hexane/ethyl acetate as eluent. The structures of the products were confirmed by comparison of 1H-NMR data with literature reports. | [References]
[1] Organic letters, 2000, vol. 2, # 8, p. 1031 - 1032
[2] Synlett, 2018, vol. 29, # 12, p. 1644 - 1648 |
|
|