Identification | Back Directory | [Name]
Benzoic acid, 4-(3-oxo-2(3H)-isothiazolyl)-, ethyl ester | [CAS]
26530-26-7 | [Synonyms]
KM04416 Ethyl 4-(3-oxoisothiazol-2(3H)-yl)benzoate Benzoic acid, 4-(3-oxo-2(3H)-isothiazolyl)-, ethyl ester | [Molecular Formula]
C12H11NO3S | [MDL Number]
MFCD00097921 | [MOL File]
26530-26-7.mol | [Molecular Weight]
249.29 |
Chemical Properties | Back Directory | [Melting point ]
142-144 °C(Solv: toluene (108-88-3)) | [Boiling point ]
404.8±47.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-3.20±0.20(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2]. | [References]
[1] Sehyun Oh, et al. Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression. Theranostics. 2023 Jan 1;13(2):438-457. DOI:10.7150/thno.75973 [2] Gurmit Singh, et al. Mitochondrial FAD-linked Glycerol-3-phosphate Dehydrogenase: A Target for Cancer Therapeutics. Pharmaceuticals (Basel). 2014 Feb 11;7(2):192-206. DOI:10.3390/ph7020192 |
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Company Name: |
Merck KGaA
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Tel: |
21-20338288 |
Website: |
www.sigmaaldrich.cn |
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