| Identification | Back Directory | [Name]
Acetic acid, 2-[(6-benzo[b]thien-2-ylthieno[3,2-d]pyrimidin-4-yl)thio]- | [CAS]
2650530-00-8 | [Synonyms]
Acetic acid, 2-[(6-benzo[b]thien-2-ylthieno[3,2-d]pyrimidin-4-yl)thio]- | [Molecular Formula]
C16H10N2O2S3 | [MOL File]
2650530-00-8.mol | [Molecular Weight]
358.46 |
| Chemical Properties | Back Directory | [Boiling point ]
641.5±55.0 °C(Predicted) | [density ]
1.59±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
2.99±0.10(Predicted) | [color ]
white to brown |
| Hazard Information | Back Directory | [Description]
SGC-STK17B-1 is a potent and selective inhibitor of STK17B/DRAK2 kinase. | [Uses]
SGC-STK17B-1 is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC50: 34 nM, KD: 5.6 nM)[1]. | [Definition]
ChEBI: {[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanyl}acetic acid is a thienopyrimidine that is thieno[3,2-d]pyrimidine which is substituted by a (carboxymethyl)sulfanediyl group at position 4 and by a 1-benzothiophen-2-yl group at position 6. It is a STK17B kinase inhibitor. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a thienopyrimidine, a sulfur-containing carboxylic acid, a monocarboxylic acid, an aryl sulfide, a member of 1-benzothiophenes and a biaryl. | [References]
[1] Picado A, et al. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem. 2020 Dec 10;63(23):14626-14646. DOI:10.1021/acs.jmedchem.0c01174 |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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