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ChemicalBook--->CAS DataBase List--->2641079-92-5

2641079-92-5

2641079-92-5 Structure

2641079-92-5 Structure
IdentificationBack Directory
[Name]

5-(3-chlorophenylamino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide
[CAS]

2641079-92-5
[Synonyms]

CK2 inhibitor 2,CK-2 inhibitor 2
5-(3-chlorophenylamino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide
Benzo[c]-2,6-naphthyridine-8-carboxamide, 5-[(3-chlorophenyl)amino]-N-(2-hydroxyethyl)-
[Molecular Formula]

C21H17ClN4O2
[MDL Number]

MFCD34368514
[MOL File]

2641079-92-5.mol
[Molecular Weight]

392.84
Chemical PropertiesBack Directory
[Boiling point ]

691.7±55.0 °C(Predicted)
[density ]

1.420±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

12.80±0.46(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Uses]

CK2 inhibitor 2 is a potent, selective and orally active inhibitor of CK2, with an IC50 of 0.66 nM. CK2 inhibitor 2 shows high selectivity for Clk2 (IC50=32.69 nM)/CK2. CK2 inhibitor 2 exhibits favorable antiproliferative and antitumor activity[1].
[in vivo]

CK2 inhibitor 2 (60-90 mg/kg; p.o. twice a day for 4 weeks) obviously inhibits the tumor growth dose-dependently with a maximum inhibitory rate of 69% at a dose of 90 mg/kg[1].
CK2 inhibitor 2 (25 mg/kg; a single p.o.) exhibits Cmax (7017.8 ng/mL), elimination half-life (t1/2=6.67 h), and CL (0.60 L/h/kg) in SD rats[1].

Animal Model:Male BALB/c athymic nude mice (5 weeks old; 16-18 g) were injected HCT-116 cells[1]
Dosage:60, 90 mg/kg
Administration:P.o. twice a day for 4 weeks
Result:Inhibited the tumor growth in a dose-dependent manner.
No conspicuous change in body weight.
Animal Model:Sprague-Dawley (SD) rats[1]
Dosage:25 mg/kg (Pharmacokinetic Analysis)
Administration:A single p.o.
Result:Cmax=7017.8 ng/mL, t1/2=6.67 h, CL=0.60 L/h/kg.
[IC 50]

CK2: 0.66 nM (IC50)
[References]

[1] Wang Y, et, al. Discovery of 5-(3-Chlorophenylamino)benzo[ c][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition. J Med Chem. 2021 Apr 22;64(8):5082-5098. DOI:10.1021/acs.jmedchem.1c00131
Spectrum DetailBack Directory
[Spectrum Detail]

5-(3-chlorophenylamino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide(2641079-92-5)1HNMR
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