| Identification | Back Directory | [Name]
(3R)-3-[[5-Chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-1-piperidineacetamide | [CAS]
2634811-35-9 | [Synonyms]
(3R)-3-[[5-Chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-N-[4-(1,3,2-dithiarsolan-2-yl)phenyl]-1-piperidineacetamide | [Molecular Formula]
C27H28AsClN6OS2 | [MOL File]
2634811-35-9.mol | [Molecular Weight]
627.06 |
| Hazard Information | Back Directory | [Uses]
ZSQ836 is an orally active dual covalent inhibitor of CDK12/CDK13, with an EC50 value of 32 nM against CDK12. ZSQ836 can induce apoptosis and exhibit anticancer activity in vivo. ZSQ836 can be used in the study of ovarian cancer[1]. | [References]
[1] Cheng L, et al. Dual inhibition of CDK12/CDK13 targets both tumor and immune cells in ovarian cancer[J]. Cancer Research, 2022, 82(19): 3588-3602. DOI:10.1158/0008-5472.CAN-22-0222 |
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