| Identification | Back Directory | [Name]
CALP3 | [CAS]
261969-05-5 | [Synonyms]
CALP3
Calcium-like peptide 3
Calcium-Like Peptide 3,CALP-3
L-Lysine, L-valyl-L-lysyl-L-phenylalanylglycyl-L-valylglycyl-L-phenylalanyl-
Calcium-Like Peptide 3 trifluoroacetate salt H-Val-Lys-Phe-Gly-Val-Gly-Phe-Lys-OH trifluoroacetate salt | [Molecular Formula]
C44H68N10O9 | [MDL Number]
MFCD06411608 | [MOL File]
261969-05-5.mol | [Molecular Weight]
881.07 |
| Hazard Information | Back Directory | [Uses]
CALP3, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia[1][2]. | [References]
[1] Manion MK, et al. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis. FASEB J. 2000 Jul;14(10):1297-306. DOI:10.1096/fj.14.10.1297
[2] Ferdek PE, et al. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death Dis. 2017 Mar 2;8(3):e2640. DOI:10.1038/cddis.2017.41 |
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