| Identification | Back Directory | [Name]
6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- | [CAS]
2588211-44-1 | [Synonyms]
Topoisomerase I inhibitor 2
6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- | [Molecular Formula]
C18H15NO3 | [MOL File]
2588211-44-1.mol | [Molecular Weight]
293.32 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect[1]. | [IC 50]
Topoisomerase I: 0.58 μM (IC50) | [References]
[1] Zhou Y, et al. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorg Chem. 2022 May. 122:105747. DOI:10.1016/j.bioorg.2022.105747 |
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