| Identification | Back Directory | [Name]
3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE | [CAS]
257292-29-8 | [Synonyms]
KF 38789
3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE
2H-Pyran-2-one, 3-[7-(2,4-dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl- | [Molecular Formula]
C19H21NO5S | [MDL Number]
MFCD00543709 | [MOL File]
257292-29-8.mol | [Molecular Weight]
375.44 |
| Hazard Information | Back Directory | [Uses]
KF 38789 inhibits the binding of U937 cells to immobilized P-selectin IgG chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM. | [Definition]
ChEBI: 3-[7-(2,4-dimethoxyphenyl)-1,4-thiazepan-5-ylidene]-6-methylpyran-2,4-dione is a dimethoxybenzene. | [Biological Activity]
Selective inhibitor of P-selectin-mediated cell adhesion (IC 50 = 1.97 μ M) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo . | [in vivo]
KF38789 can block P-selectin-mediated binding in vitro and leukocyte accumulation in vivo[1].
Intraperitoneal injection of the P-selectin inhibitor KF38789 (daily intraperitoneal injection of 10mg/kg for 12 days) significantly reduces mechanical allodynia in the facial carrageenan-injected mice[3]. | Animal Model: | BALB/c mice[1] | | Dosage: | 1 mg/kg | | Administration: | Intravenously administrated | | Result: | Significantly reduced leukocyte accumulation.
|
| Animal Model: | Twenty-four adult male C57BL/6J (B6) mice, about 6-8 weeks of age and weighing approximately 20-30 g[3] | | Dosage: | 10 mg/kg, 1 mg/kg, 0.1 mg/kg, 0.01 mg/kg or 0.001 mg/kg | | Administration: | Intraperitoneal injection daily for 12 days | | Result: | Significantly reduced mechanical allodynia in the facial carrageenan-injected mice.
|
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|