| Identification | Back Directory | [Name]
SOP1812（QN-302） | [CAS]
2546091-70-5 | [Synonyms]
QN-302
SOP1812
SOP1812（QN-302）
2,7-Bis[3-(4-morpholinyl)propyl]-4-[[2-(1-pyrrolidinyl)ethyl]amino]-9-[4-(1-pyrrolidinylmethyl)phenyl]benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone | [Molecular Formula]
C45H57N7O6 | [MOL File]
2546091-70-5.mol | [Molecular Weight]
791.98 |
| Chemical Properties | Back Directory | [density ]
1.292±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
9.86±0.20(Predicted) | [color ]
Brown to reddish brown | [InChIKey]
JQXVCGMANURRRW-UHFFFAOYSA-N | [SMILES]
C12=CC(C3=CC=C(CN4CCCC4)C=C3)=C3C4C1=C(C(NCCN1CCCC1)=CC=4C(=O)N(CCCN1CCOCC1)C3=O)C(=O)N(CCCN1CCOCC1)C2=O |
| Hazard Information | Back Directory | [Uses]
SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer[1]. | [in vivo]
SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice[1]. | Animal Model: | Female athymic nude mice with MIA PaCa-2 xenografts[1] | | Dosage: | 1 mg/kg | | Administration: | Intravenous injection; 1 mg/kg once or twice per week; for 28 days | | Result: | Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals. |
| Animal Model: | KPC mice with PDAC symptoms[1] | | Dosage: | 1 mg/kg | | Administration: | Intravenous injection; 1 mg/kg once per week; for 3 weeks | | Result: | Significantly extended survival of KPC mice and showed a better effect than gemcitabine. |
| [References]
[1] Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. DOI:10.1021/acsmedchemlett.0c00317 |
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| Company Name: |
UT gene
|
| Tel: |
15950087276 |
| Website: |
www.utgene.com |
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