| Identification | Back Directory | [Name]
AFZELECHIN | [CAS]
2545-00-8 | [Synonyms]
(2R)-2α-(4-Hydroxyphenyl)chroman-3β,5,7-triol
2H-1-Benzopyran-3,5,7-triol,3,4-dihydro-2-(4-hydroxyphenyl)-, (2R,3S)
[2R,3S,(+)]-3,4-Dihydro-2-(4-hydroxyphenyl)-2H-1-benzopyran-3,5,7-triol | [Molecular Formula]
C15H14O5 | [MDL Number]
MFCD01861520 | [MOL File]
2545-00-8.mol | [Molecular Weight]
274.27 |
| Chemical Properties | Back Directory | [Melting point ]
252-254 °C (decomp) | [Boiling point ]
583.4±50.0 °C(Predicted) | [density ]
1.492±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
9?+-.0.60(Predicted) | [color ]
White to light brown | [InChI]
InChI=1S/C15H14O5/c16-9-3-1-8(2-4-9)15-13(19)7-11-12(18)5-10(17)6-14(11)20-15/h1-6,13,15-19H,7H2/t13-,15+/m0/s1 | [InChIKey]
RSYUFYQTACJFML-DZGCQCFKSA-N | [SMILES]
[C@H]1(C2=CC=C(O)C=C2)OC2=CC(O)=CC(O)=C2C[C@@H]1O |
| Hazard Information | Back Directory | [Uses]
(+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia[1]. | [Definition]
ChEBI: A tetrahydroxyflavan that is (2S)-flavan substituted by hydroxy groups at positions 3, 5, 7 and 4' respectively. | [References]
[1] Junichi Saijyo, et al. Alpha-glucosidase Inhibitor From Bergenia Ligulata. J Oleo Sci. 2008;57(8):431-5. DOI:10.5650/jos.57.431 |
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