Identification | Back Directory | [Name]
NHTD | [CAS]
2540915-70-4 | [Synonyms]
NHTD Benzoic acid, 2,4-dihydroxy-, (2E)-2-[[3-(1,1-dimethylethyl)-6,7,8,9-tetrahydro-2-hydroxy-1-dibenzofuranyl]methylene]hydrazide | [Molecular Formula]
C24H26N2O5 | [MOL File]
2540915-70-4.mol | [Molecular Weight]
422.47 |
Hazard Information | Back Directory | [Uses]
NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC)[1]. | [IC 50]
K-RAS | [References]
[1] Leung EL, et al. Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant nonsmall cell lung cancer. Int J Cancer. 2019 Sep 1;145(5):1334-1345. DOI:10.1002/ijc.32222 |
|
|