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ChemicalBook--->CAS DataBase List--->2540915-70-4

2540915-70-4

2540915-70-4 Structure

2540915-70-4 Structure
IdentificationBack Directory
[Name]

NHTD
[CAS]

2540915-70-4
[Synonyms]

NHTD
Benzoic acid, 2,4-dihydroxy-, (2E)-2-[[3-(1,1-dimethylethyl)-6,7,8,9-tetrahydro-2-hydroxy-1-dibenzofuranyl]methylene]hydrazide
[Molecular Formula]

C24H26N2O5
[MOL File]

2540915-70-4.mol
[Molecular Weight]

422.47
Chemical PropertiesBack Directory
[density ]

1.352±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka]

8.005±0.35(predicted)
Hazard InformationBack Directory
[Uses]

NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC)[1].
[IC 50]

K-RAS
[References]

[1] Leung EL, et al. Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant nonsmall cell lung cancer. Int J Cancer. 2019 Sep 1;145(5):1334-1345. DOI:10.1002/ijc.32222
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