| Identification | Back Directory | [Name]
UROTENSIN II (HUMAN) | [CAS]
251293-28-4 | [Synonyms]
UTS2
Urotensin-2
U-II (huMan)
UROTENSIN II (HUMAN)
Urotensin II, human (3)
Urotensin II (114-124), human
M.W. 1388.57 C64H85N13O18S2
Urotensin II human, ≥97% (HPLC)
UROTENSIN II (HUMAN) HYDROCHLORIDE
ETPDCFWKYCV, HCL (DISULFIDE BRIDGE: 5-10)
GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL
H-GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL-OH
ANTI-UTS2(N-TERMINAL) antibody produced in rabbit
GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL HYDROCHLORIDE
H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH (Cys5-Cys10)
H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH, (Disulfide bond)
L-Ala-Gly-L-Thr-L-Ala-L-Asp-L-Cys-L-Phe-L-Trp-L-Lys-L-Tyr-L-Cys-L-Val-OH
GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL(DISULFIDE BRIDGE:CYS5-CYS10)
Ala-Gly-Thr-Ala-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val [Disulfide bridge: 6–11]
H-GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL-OH, HCL (DISULFIDE BRIDGE: 5-10)
L-Valine, L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-, cyclic (5→10)-disulfide | [Molecular Formula]
C64H85N13O18S2 | [MDL Number]
MFCD02261967 | [MOL File]
251293-28-4.mol | [Molecular Weight]
1388.57 |
| Chemical Properties | Back Directory | [Boiling point ]
1760.5±65.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
H2OPeptide Solubility and Storage Guidelines:1.??Calculate the length of the peptide.2.??Calculate the overall charge of the entire peptide according to the following table:3.??Recommended solution: | [form ]
Solid | [pka]
3.60±0.10(Predicted) | [biological source]
synthetic | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: Cys5-Cys7) |
| Hazard Information | Back Directory | [Uses]
Urotensin II human was used in agonist and antagonist preparation for calcium mobilization assay. The product can also be used as a test compound for studying the impact of dihydropyridine calcium antagonist amlodipine in human internal mammary artery and clinical implications. | [Biochem/physiol Actions]
Human urotensin II is a vasoactive neuropeptide that belongs to CRF family and stimulates arterial smooth muscle contraction, actin stress fiber formation and proliferation via small GTPase RhoA and there downstream effector Rho-kinase activation.The product is also a selective and potent vasoconstrictor agent as well as an agonist for the orphan receptor GPR14. | [in vivo]
Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1]. | [storage]
Desiccate at -20°C |
|
|