| Identification | Back Directory | [Name]
FRATIDE | [CAS]
251087-38-4 | [Synonyms]
FRATIDE
M.W. 4534.11 C192H327N67O60
L-Glutamine, L-seryl-L-glutaminyl-L-prolyl-L-a-glutamyl-L-threonyl-L-arginyl-L-threonylglycyl-L-a-aspartyl-L-a-aspartyl-L-a-aspartyl-L-prolyl-L-histidyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-glut
aminyl-L-leucyl-L-valyl-L-leucyl-L-serylglycyl-L-asparaginyl-L-leucyl-L-isoleucyl-L-lysyl-L-a-glut
L-Glutamine, L-seryl-L-glutaminyl-L-prolyl-L-a-glutamyl-L-threonyl-L-arginyl-L-threonylglycyl-L-a-aspartyl-L-a-aspartyl-L-a-aspartyl-L-prolyl-L-histidyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-glut
aminyl-L-leucyl-L-valyl-L-leucyl-L-serylglycyl-L-asparaginyl-L-leucyl-L-isoleucyl-L-lysyl-L-a-glutamyl-L-alanyl-L-valyl-L-arginyl-L-arginyl-L-leucyl-L-histidyl-L-seryl-L-arginyl-L-arginyl-L-leucyl- (9
CI)
L-Seryl-L-glutaminyl-L-prolyl-L-alpha-glutamyl-L-threonyl-L-arginyl-L-threonylglycyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alpha-aspartyl-L-prolyl-L-histidyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-leucyl-L-valyl-L-leucyl-L-serylglycyl-L-asparaginyl-L-leucyl-L-isoleucyl-L-lysyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-arginyl-L-arginyl-L-leucyl-L-histidyl-L-seryl-L-arginyl-L-arginyl-L-leucyl-L-glutamine | [Molecular Formula]
C192H327N67O60 | [MDL Number]
MFCD04974166 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble in DMSO | [form ]
solid | [color ]
White lyophilised | [Sequence]
Ser-Gln-Pro-Glu-Thr-Arg-Thr-Gly-Asp-Asp-Asp-Pro-His-Arg-Leu-Leu-Gln-Gln-Leu-Val-Leu-Ser-Gly-Asn-Leu-Ile-Lys-Glu-Ala-Val-Arg-Arg-Leu-His-Ser-Arg-Arg-Leu-Gln |
| Hazard Information | Back Directory | [Description]
Inhibitor of glycogen synthase kinase-3 (GSK-3); derived from FRAT1, the mammalian version of GSK-3-binding protein. Binds to GSK-3, inhibiting its interaction with axin, and also blocks GSK-3-catalyzed phosphorylation of axin and β-catenin. Does not affect GSK-3-mediated phosphorylation of glycogen synthase or eIF2B. | [Uses]
FRATtide is a peptide derived from the GSK-3 binding protein that inhibits the phosphorylation of Axin and β-catenin. FRATtide inhibits GSK-3 binding to Axin[1]. | [References]
[1] Bax B, et al. The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. Structure. 2001 Dec;9(12):1143-52. DOI:10.1016/s0969-2126(01)00679-7 |
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