Identification | Back Directory | [Name]
1-Azabicyclo[2.2.2]octane, 3,3'-[1,3-phenylenebis(2-propyne-3,1-diyloxy-1,2,5-thiadiazole-4,3-diyl)]bis-, (3S,3'S)- (9CI) | [CAS]
250649-13-9 | [Synonyms]
NNC11-1607 NNC 11-1607 NNC-11-1607 1-Azabicyclo[2.2.2]octane, 3,3'-[1,3-phenylenebis(2-propyne-3,1-diyloxy-1,2,5-thiadiazole-4,3-diyl)]bis-, (3S,3'S)- (9CI) | [Molecular Formula]
C30H32N6O2S2 | [MOL File]
250649-13-9.mol | [Molecular Weight]
572.74 |
Hazard Information | Back Directory | [Description]
NNC 11-1607 is a novel functionally selective M(1)/M(4) mAChR agonist. | [Uses]
NNC 11-1607 is a selective M1/M4 muscarinic acetylcholine receptor (mAChR) agonist. NNC 11-1607 inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in Chinese hamster ovary cells expressing the human M2 or M4 mAChR. NNC 11-1607 is promising for research of central nervous system disorders, such as Alzheimer’s disease and schizophrenia[1]. | [References]
[1] Christopoulos A, et al. Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1260-8. PMID:11504829 |
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