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ChemicalBook--->CAS DataBase List--->250159-48-9

250159-48-9

250159-48-9 Structure

250159-48-9 Structure
IdentificationBack Directory
[Name]

(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate
[CAS]

250159-48-9
[Synonyms]

Miriplatin hydrate
Miriplatin monohydrate
(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate
[Molecular Formula]

C34H70N2O5Pt
[MDL Number]

MFCD22572709
[MOL File]

250159-48-9.mol
[Molecular Weight]

782.008
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

25℃: DMSO
[form ]

Powder
Hazard InformationBack Directory
[Uses]

Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents.
[Biological Activity]

Miriplatin hydrate (SM-11355 hydrate) is an effective chemotherapeutic agent and is a kind of alkylator.
[in vitro]

Miriplatin suspended in lipiodol (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis.

[in vivo]

Miriplatin (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells.

[storage]

Store at -20°C
[References]

[1] Kishimoto S, et al. Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration. Biol Pharm Bull. 2000 Mar;23(3):344-8. DOI:10.1248/bpb.23.344
[2] Hanada M, et al. Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis. Cancer Chemother Pharmacol. 2009 Aug;64(3):473-83. DOI:10.1007/s00280-008-0895-3
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