| Identification | Back Directory | [Name]
1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]- | [CAS]
2493426-43-8 | [Synonyms]
HIV-1 inhibitor-43
1H-Indole-2-carboxamide, 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-N-[(2-hydroxyphenyl)methyl]- | [Molecular Formula]
C24H21ClN2O4S | [MOL File]
2493426-43-8.mol | [Molecular Weight]
468.95 |
| Hazard Information | Back Directory | [Uses]
HIV-1 inhibitor-43 is a potent HIV-1 inhibitor with an EC50 of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24 expression[1]. | [IC 50]
HIV-1 (Y188L): 21.3 nM (EC50); HIV-1 (K103N+Y181C): 6.2 nM (EC50); HIV-1 (K103N): <0.7 nM (EC50); HIV-1 (Y181C): <0.7 nM (EC50) | [References]
[1] Nalli M, et al. New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains. Eur J Med Chem. 2020 Dec 15;208:112696. DOI:10.1016/j.ejmech.2020.112696 |
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