| Identification | Back Directory | [Name]
2-Pyrazinecarboxamide, N-[4-[4-amino-6-ethynyl-5-(3-quinolinyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]bicyclo[2.2.1]hept-1-yl]-5-methyl- | [CAS]
2472802-77-8 | [Synonyms]
2-Pyrazinecarboxamide, N-[4-[4-amino-6-ethynyl-5-(3-quinolinyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]bicyclo[2.2.1]hept-1-yl]-5-methyl- | [Molecular Formula]
C30H26N8O | [MOL File]
2472802-77-8.mol | [Molecular Weight]
514.58 |
| Hazard Information | Back Directory | [Uses]
Emupertinib (example 37) is a potent EGFR inhibitor with IC50 values of <0.3 nM, 0.52 nM, 0.5 nM, 0.69 nM and 0.92 nM for EGFR (d746-750/T790M/C779S), EGFR (L858R/T790M/C797S), EGFR (d746-750/C797S), EGFR (L858R/C797S), and EGFR (wild-type), respectively[1]. | [IC 50]
EGFR (L858R/T790M/C797S): 0.52 nM (IC50); EGFR (d746-750/T790M/C779S): <0.3 nM (IC50); EGFR (d746-750/C797S): 0.5 nM (IC50); EGFR (WT): 0.92 nM (IC50) | [References]
[1] 冬樹 山本, et al. 7H-pyrrolo [2,3-d] pyrimidine-4-amine derivative. |
|
|