| Identification | Back Directory | [Name]
(4-BROMO-2-FORMYLPHENOXY)ACETIC ACID | [CAS]
24589-89-7 | [Synonyms]
AKOS B005879
(4-BROMO-2-FORMYLPHENOXY)ACETIC ACID
2-(4-bromo-2-formylphenoxy)acetic acid
Acetic acid, 2-(4-bromo-2-formylphenoxy)-
2-(4-bromo-2-methanoyl-phenoxy)ethanoic acid
3-Pyridinecarboxylicacid,2,7-dimethyl-,methylester | [Molecular Formula]
C9H7BrO4 | [MDL Number]
MFCD02257408 | [MOL File]
24589-89-7.mol | [Molecular Weight]
259.05 |
| Chemical Properties | Back Directory | [Boiling point ]
413.6±30.0 °C(Predicted) | [density ]
1.699±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
2.96±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
Ethyl (4-bromo-2-formylphenoxy)acetate (60 g, 0.209 mol) was added to a mixture of LiOH (7.5 g, 0.31 mol), THF (250 mL) and water (100 mL) and stirred for 24 h at room temperature. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was acidified to pH=2 with 1.5 N HCl. The resulting solid precipitate was filtered and dried to afford (4-bromo-2-formylphenoxy)acetic acid (50 g, 94% yield). | [References]
[1] Patent: WO2004/7491, 2004, A1. Location in patent: Page 51
[2] Organic Letters, 2015, vol. 17, # 23, p. 5824 - 5827
[3] European Journal of Medicinal Chemistry, 1999, vol. 34, # 12, p. 1061 - 1070 |
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