| Identification | Back Directory | [Name]
LIDORESTAT | [CAS]
245116-90-9 | [Synonyms]
IDD-676
LIDORESTAT
LIDORESTATUM
3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid
[3-(4,5,7-Trifluorobenzothiazol-2-ylmethyl)indol-1-yl]acetic acid
1H-Indole-1-aceticacid, 3-[(4,5,7-trifluoro-2-benzothiazolyl)methyl]-
2-(3-((4,5,7-TRIFLUOROBENZO[D]THIAZOL-2-YL)METHYL)-1H-INDOL-1-YL)ACETIC ACID | [Molecular Formula]
C18H11F3N2O2S | [MDL Number]
MFCD08067733 | [MOL File]
245116-90-9.mol | [Molecular Weight]
376.35 |
| Chemical Properties | Back Directory | [Melting point ]
177-178℃ | [Boiling point ]
591.4±50.0 °C(Predicted) | [density ]
1.55 | [form ]
Solid | [pka]
4.23±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Treat ment of diabetic complications, including neuropathy,
retinopathy, cataracts, nephropathy (selective aldose
reductase inhibitor). | [in vivo]
Lidorestat (25 mg/kg/day; oral administration; twice daily; for 6 weeks; diabetic mice) treatment decreases fructose and reduces mortality in diabetic hAR-expressing mice. And Lidorestat does not affect weight[1]. | Animal Model: | Diabetic low-density lipoprotein (LDL) receptor-deficient [Ldlr(-/-)] mice[1] | | Dosage: | 25 mg/kg/day | | Administration: | Oral administration; twice daily; for 6 weeks | | Result: | Diabetic hAR-expressing mice had decreased fructose and reduced mortality.
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Cochemical Ltd.
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029-86115547 17791676824 |
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www.cochemical.com |
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Wuxi AppTec
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022-59987777 13552403979 |
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3A Chemicals
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400-668-9898 |
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www.3achem.com |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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