| Chemical Properties | Back Directory | [density ]
1.40±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
13.32±0.46(predicted) | [Sequence]
{Nle}-Pro-{d-Phe}-Arg-{d-Trp}-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg-NH2 |
| Hazard Information | Back Directory | [Uses]
GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC50=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of MC2R[1]. | [References]
[1] Bouw E, et al. Development of potent selective competitive-antagonists of the melanocortin type 2 receptor[J]. Molecular and Cellular Endocrinology, 2014, 394(1-2): 99-104. DOI:10.1016/j.mce.2014.07.003 |
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