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ChemicalBook--->CAS DataBase List--->2444364-04-7

2444364-04-7

2444364-04-7 Structure

2444364-04-7 Structure
IdentificationBack Directory
[Name]

Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-
[CAS]

2444364-04-7
[Synonyms]

EGFR/HER2/TS-IN-2
Acetamide, 2-[[5-cyano-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-2-pyrimidinyl]thio]-N-(6-methyl-2-benzothiazolyl)-
[Molecular Formula]

C26H21N7OS2
[MOL File]

2444364-04-7.mol
[Molecular Weight]

511.62
Chemical PropertiesBack Directory
[density ]

1.41±0.1 g/cm3(Predicted)
[pka]

8.10±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 μM[1].
[IC 50]

HER2: 0.125 ± 0. μM (IC50); EGFR: 0.173 ± 0. μM (IC50)
[References]

[1] Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976. DOI:10.1016/j.bioorg.2020.103976
2444364-04-7 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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