| Identification | Back Directory | [Name]
Carbamic acid, N-[6-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-1,6-dioxohexyl]amino]hexyl]-, 1,1-dimethylethyl ester | [CAS]
2435808-02-7 | [Synonyms]
Pomalidomide-amido-C4-amido-C6-NH-Boc
tert-butyl (6-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentanamido)hexyl)carbamate
Carbamic acid, N-[6-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-1,6-dioxohexyl]amino]hexyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C30H41N5O8 | [MOL File]
2435808-02-7.mol | [Molecular Weight]
599.68 |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-amido-C4-amido-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. | [IC 50]
Cereblon | [References]
[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21. DOI:10.1021/acs.jmedchem.9b00919 |
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