38846-64-9

24257-93-0

General procedure for the synthesis of 2-acetylbenzaldehyde using 2-ethynylbenzaldehyde as starting material: the general method was as follows: first, AgBArF (97.1 mg, 0.1 mmol) was accurately weighed and placed in a long-necked glass reactor, followed by the addition of 2-ethynylbenzaldehyde (1 mmol). Next, 10 μL of ethyl acetate (EtOAc) was added and stirred for 5 min. After that, n-dodecane (1 mmol), an internal standard, and 3 mL of deionized water were added, and the reaction device was placed in an oil bath at 80 °C with continuous stirring and heated for 12 to 24 hours. Upon completion of the reaction, the reaction device was opened and 3 mL of ethyl acetate (EtOAc) was added to it and stirred for 5 minutes, after which the organic phase was separated and collected. The organic phase was passed through a short silica gel column to remove possible impurities and subsequently analyzed by GC-MS. Finally, the product was purified by silica gel column chromatography using a hexane/ethyl acetate (EtOAc) solvent mixture as eluent. The purified product was structurally characterized by 1H NMR and ESI-MS.